Tesamorelin
đź“ť LAB NOTES
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) studied for its activity within the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) signaling pathways. Research has examined its influence on body composition, visceral adipose tissue, lipid metabolism, hepatic fat accumulation, and broader metabolic processes.
As a GHRH analog, tesamorelin is of particular research interest for investigating endogenous growth hormone secretion and the relationship between GH/IGF-1 signaling, adipose tissue distribution, metabolic regulation, and body composition.
TARGETED RESEARCH USE
GHRH receptor signaling, endogenous growth hormone secretion, GH and IGF-1 pathways, visceral adipose tissue, body composition, lipid metabolism, hepatic fat research, adipose tissue biology, and metabolic regulation.
RESEARCH REFERENCES
Falutz J, Allas S, Blot K, et al. Metabolic Effects of a Growth Hormone-Releasing Factor in Patients With HIV. New England Journal of Medicine. 2007;357(23):2359–2370. — View Study on PubMed
Falutz J, Mamputu JC, Potvin D, et al. Effects of Tesamorelin, a Growth Hormone-Releasing Factor, in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial With a Safety Extension. Journal of Acquired Immune Deficiency Syndromes. 2010;53(3):311–322. — View Study on PubMed
Stanley TL, Feldpausch MN, Oh J, et al. Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Clinical Trial. JAMA. 2014;312(4):380–389. — View Study on PubMed
Stanley TL, Fourman LT, Zheng I, et al. Effects of Tesamorelin on Non-Alcoholic Fatty Liver Disease in HIV: A Randomised, Double-Blind, Multicentre Trial. The Lancet HIV. 2019;6(12)–e830. — View Study on PubMed
⚠️ FOR RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL USE
This research compound is supplied as a lyophilized powder in a sealed 3 mL vial to support stability and proper laboratory handling. Certificate of Analysis (COA) available for verification. Reconstitution is required prior to research use.