MOTS-C
đź“ť LAB NOTES
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide studied for its role in cellular metabolism, mitochondrial signaling, energy regulation, glucose utilization, insulin sensitivity, and adaptive responses to metabolic stress. Unlike most peptides encoded by nuclear DNA, MOTS-c is encoded within mitochondrial DNA, making it of particular interest in research exploring communication between the mitochondria and the nucleus.
Research has also examined MOTS-c in relation to exercise physiology, skeletal muscle metabolism, metabolic homeostasis, cellular stress adaptation, and age-related biological processes.
TARGETED RESEARCH USE
Mitochondrial signaling, cellular energy metabolism, glucose utilization, insulin sensitivity, metabolic homeostasis, skeletal muscle metabolism, exercise-related biological pathways, cellular stress adaptation, AMPK signaling, mitochondrial-to-nuclear communication, and aging-related research.
RESEARCH REFERENCES
Lee C, Zeng J, Drew BG, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism. 2015;21(3):443–454. — View Study on PubMed
Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metabolism. 2018;28(3):516–524.e7. — View Study on PubMed
Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis. Nature Communications. 2021;12:470. — View Full Study on PubMed Central
Dieli-Conwright CM, Sami N, Norris MK, et al. Effect of Aerobic and Resistance Exercise on the Mitochondrial Peptide MOTS-c in Adults. Research continues to investigate the relationship between MOTS-c, physical activity, metabolism, and mitochondrial function. — Explore MOTS-c Research on PubMed
⚠️ FOR RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL USE
This research compound is supplied as a lyophilized powder in a sealed 3 mL vial to support stability and proper laboratory handling. Certificate of Analysis (COA) available for verification. Reconstitution is required prior to research use.