PEP-Rt
đź“ť LAB NOTES
PEP-Rt is an investigational triple receptor agonist studied for its activity at the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors. Research has focused on its influence on metabolic signaling, appetite regulation, energy expenditure, glucose and lipid metabolism, insulin sensitivity, and body-weight regulation.
Its simultaneous activity across three distinct metabolic receptor pathways makes PEP-Rt of particular research interest for investigating the complex biological mechanisms involved in energy balance, nutrient metabolism, and metabolic function.
TARGETED RESEARCH USE
GIP, GLP-1, and glucagon receptor signaling, metabolic regulation, appetite and satiety pathways, energy expenditure, glucose metabolism, insulin sensitivity, lipid metabolism, body-weight regulation, adipose tissue biology, and obesity-related metabolic research.
RESEARCH REFERENCES
Jastreboff AM, Kaplan LM, FrĂas JP, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine. 2023;389:514–526. — View Study on PubMed
Rosenstock J, Frias J, Jastreboff AM, et al. Retatrutide, a GIP, GLP-1 and Glucagon Receptor Agonist, for People With Type 2 Diabetes: A Randomised, Double-Blind, Placebo and Active-Controlled, Parallel-Group, Phase 2 Trial. The Lancet. 2023;402(10401):529–544. — View Study on PubMed
Coskun T, Urva S, Roell WC, et al. LY3437943, a Novel Triple GIP, GLP-1, and Glucagon Receptor Agonist for Glycemic Control and Weight Loss: From Discovery to Clinical Proof of Concept. Cell Metabolism. 2022;34(9):1234–1247.e9. — View Study on PubMed
Sanyal AJ, Kaplan LM, Frias JP, et al. Retatrutide Treatment for Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease: Findings From a Randomized Phase 2 Trial. Research has examined retatrutide's effects on liver fat and related metabolic parameters. — Explore Retatrutide Research on PubMed
⚠️ FOR RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL USE
This research compound is supplied as a lyophilized powder in a sealed 3 mL vial to support stability and proper laboratory handling. Certificate of Analysis (COA) available for verification. Reconstitution is required prior to research use.