5-Amino-1mq
đź“ť LAB NOTES
5-Amino-1MQ is a small-molecule research compound studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism, methylation, energy regulation, and adipose tissue biology. Research has explored NNMT inhibition as a potential mechanism for influencing metabolic pathways associated with fat-cell function, energy expenditure, body-weight regulation, insulin sensitivity, and cellular NAD+ metabolism.
Unlike peptide-based research compounds, 5-Amino-1MQ is a small molecule that is of particular research interest for investigating how modulation of NNMT activity may affect metabolic homeostasis and adipose tissue function.
TARGETED RESEARCH USE
NNMT inhibition, cellular metabolism, adipose tissue biology, energy expenditure, lipid and fat metabolism, body-weight regulation, insulin sensitivity, metabolic homeostasis, methylation pathways, and NAD+ metabolism.
RESEARCH REFERENCES
Kraus D, Yang Q, Kong D, et al. Nicotinamide N-Methyltransferase Knockdown Protects Against Diet-Induced Obesity. Nature. 2014;508(7495):258–262. — View Study on PubMed
Neelakantan H, Vance V, Wetzel MD, et al. Selective and Membrane-Permeable Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Reverse High-Fat Diet-Induced Obesity in Mice. Biochemical Pharmacology. 2018;147:141–152. — View Study on PubMed
Neelakantan H, Brightwell CR, Graber TG, et al. Small Molecule Nicotinamide N-Methyltransferase Inhibitor Activates Senescent Muscle Stem Cells and Improves Regenerative Capacity of Aged Skeletal Muscle. Biochemical Pharmacology. 2019;163:481–492. — View Study on PubMed
Eckert MA, Coscia F, Chryplewicz A, et al. Proteomics Reveals NNMT as a Master Metabolic Regulator of Cancer-Associated Fibroblasts. Nature. 2019;569(7758):723–728. — View Study on PubMed
⚠️ FOR RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL USE
This research compound is supplied as a lyophilized powder in a sealed 3 mL vial to support stability and proper laboratory handling. Certificate of Analysis (COA) available for verification. Reconstitution is required prior to research use.